In medicine, agenesis (/ˈɛnəsəs/[1]) refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue. Many forms of agenesis are referred to by individual names, depending on the organ affected:

  • Agenesis of the corpus callosum - failure of the Corpus callosum to develop
  • Renal agenesis - failure of one or both of the kidneys to develop
  • Amelia - failure of the arms or legs to develop
  • Penile agenesis - failure of penis to develop
  • Müllerian agenesis - failure of the uterus and part of the vagina to develop
  • Agenesis of the gallbladder - failure of the Gallbladder to develop. A person may not realize they have this condition unless they undergo surgery or medical imaging, since the gallbladder is neither externally visible nor essential.

Eye agenesis

Eye agenesis is a medical condition in which people are born with no eyes.

Dental & oral agenesis

Ear agenesis

Ear agenesis is a medical condition in which people are born without ears.

Because the middle and inner ears are necessary for hearing, people with complete agenesis of the ears are totally deaf. Minor agenesis that affects only the visible parts of the outer ear, which may be called microtia, typically produces cosmetic concerns and perhaps hearing impairment if the opening to the ear canal is blocked, but not deafness.


  1. ^ Entry "agenesis" in Merriam-Webster Online Dictionary.
  2. ^ Rozkovcová, E.; Marková, M.; Dolejší, J. (1999). "Studies on agenesis of third molars amongst populations of different origin". Sborník Lékařský. 100 (2): 71–84. PMID 11220165.