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Professor Raymond Gosling in 2003 "DNA at King's – the continuing story: 50th anniversary of the discovery of the structure of DNA"
|Born||(1926-07-15)15 July 1926
Wembley, London, England
|Died||18 May 2015(2015-05-18) (aged 88)|
|Residence||London, United Kingdom|
|Alma mater||University College London
King's College London
|Institutions||King's College London|
Raymond George Gosling (15 July 1926 – 18 May 2015) was a British scientist. While a PhD student at King's College, London he worked under the supervision of Rosalind Franklin. Their crystallographic experiments, together with those of Maurice Wilkins of the same laboratory, produced data that helped James Watson and Francis Crick to infer the structure of DNA.
He was born in 1926 and attended school in Wembley. He studied physics at University College London from 1944 to 1947 and became a hospital physicist at the King's Fund and Middlesex Hospital between 1947 and 1949 before joining King's College London as a research student where he eventually received his PhD.
Work at King's College London and DNA
At King's College London, Gosling worked on X-ray diffraction with Maurice Wilkins, analysing samples of DNA which they prepared by hydrating and drawing out into thin filaments and photographing in a hydrogen atmosphere.
Gosling was then assigned to Rosalind Franklin when she joined King's College in 1951. They worked under the direction of Sir John Randall. Together they produced the first X-ray diffraction photographs of the "form B" paracrystalline arrays of highly hydrated DNA. During the next two years, the pair worked closely together to perfect the technique of x-ray diffraction photography of DNA and obtained at the time the sharpest diffraction images of DNA. Gosling made the X-ray diffraction image of DNA known as Photograph 51. This work led directly to the 1962 Nobel Prize for Physiology or Medicine being awarded to Francis Crick, James D. Watson and Maurice Wilkins. Gosling was the co-author with Franklin of one of the three DNA double helix papers published in Nature in April 1953.
Gosling briefly remained at King's College following the completion of his thesis in 1954 before lecturing in physics at Queen's College, University of St Andrews, and at the University of the West Indies.
Work at Guy's Hospital
He returned to the UK in 1967 and became Lecturer and Reader at Guy's Hospital Medical School, and Professor and Emeritus Professor in Physics Applied to Medicine from 1984. Here he helped develop the underlying basic medical science and technology for haemodynamic doppler ultrasound vascular assessment in the Non Invasive Angiology Group, and set up the clinical Ultrasonic Angiology Unit.
Gosling served on numerous committees of the University of London, notably relating to radiological science, and retained an active professional involvement in medical physics almost to the end of his life.
References and Sources
- "King's College biography". Retrieved 29 November 2006.
- Wilkins, M.; Gosling, R.; Seeds, W. (1951). "Physical studies of nucleic acid". Nature. 167 (4254): 759–760. Bibcode:1951Natur.167..759W. doi:10.1038/167759a0. PMID 14833383.
- Gosling, R.; Tickle, C.; Running, S. W.; Tandong, Y.; Dinnyes, A.; Osowole, A. A.; Cule, E. (2011). "Seven ages of the PhD". Nature. 472 (7343): 283–286. Bibcode:2011Natur.472..283G. doi:10.1038/472283a.
- "Due credit". Nature. 496: 270. 18 April 2013. doi:10.1038/496270a.
- Franklin, R. E.; Gosling, R. G. (1953). "Molecular Configuration in Sodium Thymonucleate". Nature. 171 (4356): 740–741. Bibcode:1953Natur.171..740F. doi:10.1038/171740a0. PMID 13054694.
- Side, C. D.; Gosling, R. G. (1971). "Non-surgical Assessment of Cardiac Function". Nature. 232 (5309): 335–336. Bibcode:1971Natur.232..335S. doi:10.1038/232335a0. PMID 5094838.
- Laogun, A. A.; Gosling, R. G. (1982). "In vivo arterial compliance in man". Clinical Physics and Physiological Measurement. 3 (3): 201–212. Bibcode:1982CPPM....3..201L. doi:10.1088/0143-0815/3/3/004. PMID 7140158.
- Kontis, S.; Gosling, R. G. (1987). "A computerized method for processing of spectrally analysed Doppler-shifted signals from insonated arteries". Journal of Medical Engineering & Technology. 11 (3): 108–112. doi:10.3109/03091908709018151.
- Baskett, J. J.; Lewis, R. R.; Beasley, M. G.; Gosling, R. G. (1990). "Changes in Carotid Artery Compliance with Age". Age and Ageing. 19 (4): 241–246. doi:10.1093/ageing/19.4.241. PMID 2220482. - Abstract
- Professor Raymond Gosling
- Detailed interview 2013 in Genome Biology
- Raymond Gosling in The King's story
- Doppler-shifted ultrasound units (1974–1981) jointly developed by Dr.B.A.Coghlan and Prof.R.G.Gosling's Blood Flow Group at the Physics Dept., Guy's Hospital Medical School, London. These early devices were used for haemodynamic assessment of normal volunteers and assessment of patients with peripheral vascular disease. The work reflects a close and extensive collaboration with Dr.M.G.Taylor.
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